Immune-related gene polymorphisms in pulmonary diseases
نویسندگان
چکیده
منابع مشابه
[DNA polymorphisms of the age-related gene in geriatric diseases].
老化の機序 を説明する場合, プログラム説 (遺伝 因子) とエラー蓄積説 (環境因子) の二大学説がある. プログ ラム説では, 老化は生殖の後 に進行する必然的な事柄で, 遺伝子 レベルであらかじめ決定されている過程であると する説である. エラー蓄積説は, 生体に対する紫外線な どの障害や老廃物の蓄積がDNAや 蛋白質に発生 し, 最 終的には致命的な障害 となるとする説である. この二つ の機構が互いに関連しながら老化は進むものと考えられ る. プログラム説を支持する事実としては, 遺伝的にそ の発症が規定されている早老症の存在がある. 多 くの遺 伝性早老症は特定の臓器の老化症状 を発現するため, 本 来の老化そのものを反映していないが, 原因となる遺伝 子を調べれば, 分子遺伝学的側面からの老化機構解明の 糸口になるものと期待 される. ウェルナー症候群 (WS) は遺伝...
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ژورنال
عنوان ژورنال: Toxicology
سال: 2017
ISSN: 0300-483X
DOI: 10.1016/j.tox.2017.03.020